Updated October 2026

Largest primary care groups in South Carolina

Medical group directory
South Carolina
Primary care

Groups: 448
Internal Medicine groups: 177
Nurse Practitioner groups: 123
Internal medicine specialists: 2,361
Nurse practitioner specialists: 379

There are 448 primary care groups in South Carolina with a Medicare PAC ID: 177 internal medicine, 123 nurse practitioner, 122 family medicine and 25 physician assistant. Prisma Health Medical Group is the largest internal medicine group, with 369 internal medicine specialists, and CVS MinuteClinic the largest nurse practitioner group, with 99 nurse practitioner specialists.

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Prisma Health Medical Group is the largest primary care group in South Carolina, with 1,915 physicians

Ranked by physicians with a South Carolina address linked to each group. MUSC Health is second with 1,364, and MUSC Community Physicians third with 965. 22 South Carolina groups have 100 or more physicians.

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Primary care groups in South Carolina, ranked by physicians, 51 to 100
#	Medical group	Parent organization	Physicians	HCPs	Decision makers
51	Coastal Carolina Surgical SpecialistsSummerville · 17 sites	Parent on file	23	47	Decision makers
52	New Horizon Family Health ServicesGreenville · 10 sites	Parent on file	23	43	Decision makers
53	Columbia NephrologyColumbia · 5 sites	-	22	36	Decision makers
54	Low Country Health Care System, Inc.Fairfax · 12 sites	Parent on file	19	54	Decision makers
55	Carolina Nephrology, PAGreenville · 9 sites	-	19	38	Decision makers
56	Articularis Healthcare GroupSummerville · 21 sites	-	18	32	Decision makers
57	Physicians Services GroupGreenville · 6 sites	Parent on file	17	57	Decision makers
58	Hampton Regional Medical CenterVarnville · 1 site	Parent on file	17	32	Decision makers
59	Carolina Cardiology AssociatesRock Hill · 4 sites	Parent on file	17	19	Decision makers
60	Genesis Healthcare, Inc.Columbia · 8 sites	Parent on file	16	44	Decision makers
61	Novant Health Urgent CareAnderson · 51 sites	Parent on file	15	79	Decision makers
62	Physicians Services Group of South CarolinaGreenville · 6 sites	Parent on file	15	54	Decision makers
63	Sandhills MedicalBethune · 13 sites	Parent on file	14	37	Decision makers
64	Providence CareRock Hill · 4 sites	Parent on file	13	43	Decision makers
65	SC Internal Medicine Associates and RehabilitationIrmo · 3 sites	-	13	33	Decision makers
66	Coastal CardiologyCharleston · 2 sites	Parent on file	13	21	Decision makers
67	Regional Medical Center (RMC)Orangeburg · 16 sites	Parent on file	12	36	Decision makers
68	Scotland Surgical & GIBennettsville · 28 sites	Parent on file	12	14	Decision makers
69	CareNow Urgent Care - Goose CreekGoose Creek · 20 sites	Parent on file	11	57	Decision makers
70	Palmetto InfusionWest Columbia · 40 sites	Parent on file	11	52	Decision makers
71	Coastal Cancer CenterMyrtle Beach · 8 sites	-	11	19	Decision makers
72	Three Rivers Medical GroupIrmo · 5 sites	Parent on file	11	17	Decision makers
73	Carolina Health CentersGreenwood · 13 sites	Parent on file	10	37	Decision makers
74	Your HealthWest Columbia · 4 sites	Parent on file	10	31	Decision makers
75	Trident Cardiology AssociatesLadson · 2 sites	-	10	19	Decision makers
76	Lowcountry Lung & Critical CareNorth Charleston · 2 sites	-	10	12	Decision makers
77	St. James Health and WellnessGeorgetown · 7 sites	Parent on file	9	23	Decision makers
78	Charleston Nephrology, Hypertension and Transplant, PLLCNorth Charleston · 2 sites	-	9	22	Decision makers
79	Primary Care AssociatesAnderson · 2 sites	-	9	13	Decision makers
80	Charleston Pulmonary AssociatesCharleston · 6 sites	-	9	12	Decision makers
81	Palmetto Primary Care PhysiciansGoose Creek · 11 sites	Parent on file	8	30	Decision makers
82	Family Health CareAiken · 5 sites	Parent on file	8	23	Decision makers
83	Lowcountry Infectious DiseasesCharleston · 4 sites	-	8	17	Decision makers
84	South Carolina Sleep MedicineSummerville · 3 sites	-	8	11	Decision makers
85	Carolina Blood and Cancer CareRock Hill · 3 sites	-	8	10	Decision makers
86	Digestive Disease Associates of York CountyRock Hill · 1 site	-	8	10	Decision makers
87	OnSite Healthcare and WellnessEasley · 1 site	-	7	33	Decision makers
88	Family Physicians of SpartanburgSpartanburg · 2 sites	-	7	21	Decision makers
89	Careteam PlusConway · 3 sites	Parent on file	7	13	Decision makers
90	Carolina Heart SpecialistsLancaster · 3 sites	Parent on file	7	12	Decision makers
91	Nephrology AssociatesRock Hill · 3 sites	-	7	11	Decision makers
92	OnSite Healthcare and WellnessEasley · 2 sites	-	6	38	Decision makers
93	OnSite Healthcare and WellnessEasley · 2 sites	-	6	34	Decision makers
94	Family Health Centers, Inc.Orangeburg · 3 sites	Parent on file	6	26	Decision makers
95	Peace Medical CenterGreenville · 3 sites	-	6	13	Decision makers
96	Piedmont Physicians at Silver Bluff Family MedicineAiken · 5 sites	Parent on file	6	13	Decision makers
97	Lowcountry Oncology AssociatesNorth Charleston · 1 site	Parent on file	6	12	Decision makers
98	Fairfield Medical AssociatesWinnsboro · 2 sites	-	6	11	Decision makers
99	Pee Dee NephrologyFlorence · 4 sites	-	6	11	Decision makers
100	Pinnacle PhysiciansNorth Charleston · 4 sites	-	6	11	Decision makers

Showing 51 to 100 of 448 primary care groups in South Carolina

Sources: Doctors and Clinicians National Downloadable File (CMS) and Dmand AI Affiliation Data

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