Lead Sponsor: St. Louis University

Collaborators: Massachusetts General Hospital, Indiana University, University of Iowa, The Cleveland Clinic, Orthopedic Research and Education Foundation, Boston Children's Hospital, University of Washington, Beth Israel Deaconess Medical Center, Johns Hopkins University, Wake Forest University, University of Oklahoma, All India Institute of Medical Sciences, University of Kansas, University of California, Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute), McGill University Health Centre/Research Institute of the McGill University Health Centre, American Academy of Orthopaedic Surgeons

Intervention / Treatment: DRUG: Zoledronic Acid

Lead Sponsor: McMaster University

Collaborators: Orthopedic Research and Education Foundation, Canadian Institutes of Health Research (CIHR), Canadian Cancer Society (CCS), The Physicians' Services Incorporated Foundation

Intervention / Treatment: DRUG: 24-Hour Prophylactic Cefazolin* Antibiotic Regimen, DRUG: 5-Days Prophylactic Cefazolin* Antibiotic Regimen