Lead Sponsor: Memorial Sloan Kettering Cancer Center

Collaborators: University of Rochester, University of California, San Francisco, University of South Florida, University of Michigan, The Cleveland Clinic, University of California, Irvine, University of Chicago, Oregon Health and Science University, University of Virginia, University of Colorado, Denver, The Methodist Hospital Research Institute, University of Washington, Washington University School of Medicine, St. Joseph Hospital of Orange, University of Vermont, Colon and Rectal Surgery Inc., John Muir Health, Medstar Health Research Institute, Creighton University Medical Center, St. Paul's Hospital, St. Joseph, Florida, Cleveland Clinic Florida

Intervention / Treatment: DRUG: Leucovorin, DRUG: Capecitabine (Xeloda®), RADIATION: intensity modulated radiotherapy (IMRT), BEHAVIORAL: Quality of Life Questionnaires, PROCEDURE: DRE-Endoscopy, DRUG: Oxaliplatin (OXAL), DRUG: 5-Fluorouracil (5-FU)