Lead Sponsor: The University of Texas Health Science Center, Houston

Collaborators: Stryker Neurovascular

Intervention / Treatment: DRUG: General Anesthesia (GA), PROCEDURE: Intra-arterial Thrombectomy, DRUG: Sedation

Lead Sponsor: Peng Roc Chen, MD

Collaborators: Yale University, University of Michigan, University of California, Irvine, Wake Forest University Health Sciences, Temple University, University of Illinois at Chicago, Thomas Jefferson University, Geisinger Clinic, Northwell Health, Lenox Hill Hospital, Weatherhead Foundation

Intervention / Treatment: DRUG: Nicardipine + Verapamil + Nitroglycerin, DRUG: Nicardipine, DRUG: Verapamil