Lead Sponsor: University of California, San Francisco

Collaborators: National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS), Department of Health and Human Services

Intervention / Treatment: BEHAVIORAL: Phone Outcome Assessment, PROCEDURE: Blood Draw for Plasma, DNA, Serum, RNA, BEHAVIORAL: In-Person Outcome Assessment, PROCEDURE: 3T Magnetic Resonance Imaging (MRI)

Lead Sponsor: University of Pennsylvania

Collaborators: National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, University of Miami, University of Pittsburgh, Duke University, University of Washington, Temple University, Thomas Jefferson University, Ohio State University

Intervention / Treatment: DEVICE: Management protocol based on ICP values only., DEVICE: Management protocol based on pBrO2 and ICP values.

Lead Sponsor: University of Texas Southwestern Medical Center