Lead Sponsor: Janssen Pharmaceutical K.K.

Intervention / Treatment: DRUG: Placebo 100 mg, DRUG: CNTO 1959 50 mg, DRUG: CTNO 1959 100 mg, DRUG: Placebo 50 mg

Lead Sponsor: Janssen Research & Development, LLC

Intervention / Treatment: DRUG: Ustekinumab, DRUG: Placebo for guselkumab, DRUG: Guselkumab, DRUG: Placebo for ustekinumab

Lead Sponsor: Dr. Reddy's Laboratories Limited

Collaborators: XenoPort, Inc.

Intervention / Treatment: DRUG: Placebo, DRUG: XP23829 400 mg QD, DRUG: XP 23829 800 mg QD, DRUG: XP23829 400 mg BID