Lead Sponsor: Ampel BioSolutions, LLC

Intervention / Treatment: OTHER: Decision Support Test

Lead Sponsor: State University of New York - Upstate Medical University

Collaborators: Cedars-Sinai Medical Center, University of Rochester, Yale University, Penn State University, Hospital for Special Surgery, New York, Ohio State University, St. Luke's Hospital and Health Network, Pennsylvania, Oklahoma City VA Health Care System

Intervention / Treatment: DRUG: Placebo, DRUG: N-acetylcysteine

Lead Sponsor: Northwell Health

Collaborators: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Intervention / Treatment: DRUG: Nelfinavir