Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Collaborators: Immune Tolerance Network (ITN), GlaxoSmithKline, PPD Development, LP, Rho Federal Systems Division, Inc.

Intervention / Treatment: DRUG: Rituximab, DRUG: Belimumab, DRUG: Placebo for Belimumab

Lead Sponsor: Mayo Clinic

Collaborators: Stanford University, University of Alabama at Birmingham, University of Michigan, Columbia University, The Cleveland Clinic, Medical College of Wisconsin, Case Western Reserve University, University Health Network, Toronto, University of Washington, Washington University School of Medicine, University of British Columbia, University of Toronto, University of Mississippi Medical Center, Ohio State University, NYU Langone Health, University of Kansas Medical Center, Sunnybrook Health Sciences Centre, University of Manchester, CHU de Quebec-Universite Laval, Florida International University, University of Arizona, Applied Health Research Centre, Fulk Family Foundation

Intervention / Treatment: DRUG: Rituximab, DRUG: Cyclosporine

Lead Sponsor: Columbia University

Collaborators: Centocor Research & Development, Inc.