Lead Sponsor: National Cancer Institute (NCI)

Collaborators: Canadian Cancer Trials Group

Intervention / Treatment: DRUG: Sunitinib Malate, PROCEDURE: Biospecimen Collection, DRUG: Crizotinib, PROCEDURE: Computed Tomography, DRUG: Cabozantinib S-malate, PROCEDURE: Bone Scan, DRUG: Savolitinib

Lead Sponsor: Alliance for Clinical Trials in Oncology

Collaborators: National Cancer Institute (NCI), Cancer Research UK, European Organisation for Research and Treatment of Cancer - EORTC, UNICANCER, Movember Foundation, Institute of Cancer Research (ICR), United Kingdom, Irish Group CTI

Intervention / Treatment: DRUG: carboplatin, DRUG: cisplatin, DRUG: paclitaxel, DRUG: ifosfamide, DRUG: G-CSF, DRUG: etoposide phosphate, DRUG: pegylated G-CSF, PROCEDURE: stem cell reinfusion

Lead Sponsor: Eli Lilly and Company

Intervention / Treatment: DRUG: Placebo, DRUG: Docetaxel, DRUG: Ramucirumab