Lead Sponsor: JHSPH Center for Clinical Trials

Collaborators: National Eye Institute (NEI)

Intervention / Treatment: DRUG: Dexamethasone intravitreal implant 0.7 mg, DRUG: Intravitreal Methotrexate 400 µg, DRUG: Intravitreal Ranibizumab 0.5 mg

Lead Sponsor: Nisha Acharya

Collaborators: Children's Hospital of Philadelphia, National Eye Institute (NEI), University of Miami, University of Utah, Children's Hospital Medical Center, Cincinnati, University of California, Davis, Vanderbilt University Medical Center, Children's Mercy Hospital Kansas City, Royal Children's Hospital, Norfolk and Norwich University Hospitals NHS Foundation Trust, Manchester University NHS Foundation Trust, Cambridge University Hospitals NHS Foundation Trust, University of Texas at Austin, Great Ormond Street Hospital for Children NHS Foundation Trust, University Hospitals Bristol and Weston NHS Foundation Trust, Alder Hey Children's NHS Foundation Trust, Newcastle-upon-Tyne Hospitals NHS Trust, Sheffield Children's NHS Foundation Trust, University Hospitals, Leicester, Colorado Retina Associates

Intervention / Treatment: OTHER: Placebo, BIOLOGICAL: Adalimumab

Lead Sponsor: JHSPH Center for Clinical Trials

Collaborators: National Eye Institute (NEI)

Intervention / Treatment: DRUG: Periocular triamcinolone 40 mg, DRUG: Intravitreal triamcinolone 4 mg, DRUG: Dexamethasone intravitreal implant