Lead Sponsor: McMaster University

Collaborators: Canadian Institutes of Health Research (CIHR), Canadian Cancer Society (CCS), Musculoskeletal Tumor Society, Hamilton Academic Health Sciences Organization, American Academy of Orthopaedic Surgeons

Intervention / Treatment: OTHER: Frequency: Every 3 Months, OTHER: Frequency: Every 6 Months, OTHER: Imaging Modality: Chest Radiograph (CXR), OTHER: Imaging Modality: Chest CT

Lead Sponsor: St. Louis University

Collaborators: Massachusetts General Hospital, Indiana University, University of Iowa, The Cleveland Clinic, Orthopedic Research and Education Foundation, Boston Children's Hospital, University of Washington, Beth Israel Deaconess Medical Center, Johns Hopkins University, Wake Forest University, University of Oklahoma, All India Institute of Medical Sciences, University of Kansas, University of California, Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute), McGill University Health Centre/Research Institute of the McGill University Health Centre, American Academy of Orthopaedic Surgeons

Intervention / Treatment: DRUG: Zoledronic Acid

Lead Sponsor: The Cleveland Clinic

Collaborators: University of Iowa, Orthopedic Research and Education Foundation, University of Florida, University of Oklahoma, Musculoskeletal Tumor Society

Intervention / Treatment: OTHER: Observational Only - Transcutaneous Oxygen Measurement