Lead Sponsor: Michael B. Atkins, MD

Collaborators: Georgetown University, Agenus Inc.

Intervention / Treatment: DRUG: Ipilimumab, DRUG: Nivolumab, DRUG: Botensilimab, DRUG: Balstilimab

Lead Sponsor: Michael B. Atkins, MD

Collaborators: Bristol-Myers Squibb, Hoosier Cancer Research Network

Intervention / Treatment: DRUG: Nivolumab 240 mg, DRUG: Ipilimumab 1mg/kg, DRUG: Nivolumab 3mg/kg, DRUG: Nivolumab 360mg

Lead Sponsor: National Cancer Institute (NCI)

Intervention / Treatment: BIOLOGICAL: Nivolumab, BIOLOGICAL: Ipilimumab, PROCEDURE: Biospecimen Collection, OTHER: Quality-of-Life Assessment, PROCEDURE: Computed Tomography, PROCEDURE: Multigated Acquisition Scan, DRUG: Trametinib Dimethyl Sulfoxide, PROCEDURE: Echocardiography Test, DRUG: Dabrafenib Mesylate