Lead Sponsor: Insmed Incorporated

Intervention / Treatment: DRUG: Placebo, DRUG: Brensocatib 10 mg, DRUG: Brensocatib 25 mg

Lead Sponsor: Kevin Winthrop

Collaborators: The University of Texas Health Science Center at Tyler, Insmed Incorporated

Intervention / Treatment: DRUG: LAI plus multi-drug regimen

Lead Sponsor: Kevin Winthrop

Collaborators: University of California, San Diego, Mayo Clinic, Patient-Centered Outcomes Research Institute, Emory University, University of California, San Francisco, Medical University of South Carolina, Stanford University, University of Miami, University of Iowa, Columbia University, University Health Network, Toronto, Kaiser Permanente, University of Washington, New York University, Johns Hopkins University, National Jewish Health, Temple University, Louisiana State University Health Sciences Center in New Orleans, University of Wisconsin, Madison, University of North Carolina, Loma Linda University, University of Kansas, The University of Texas Health Science Center at Tyler, Vancouver Clinic, Northwell Health, James A. Haley Veterans Administration Hospital

Intervention / Treatment: DRUG: Azithromycin, DRUG: Rifampin, DRUG: Ethambutol