Lead Sponsor: Columbia University

Collaborators: Bristol-Myers Squibb, National Institute of Neurological Disorders and Stroke (NINDS), Pfizer, Medical University of South Carolina, University of Cincinnati, Roche Pharma AG, University of Washington, Weill Medical College of Cornell University

Intervention / Treatment: DRUG: Aspirin, DRUG: Apixaban

Lead Sponsor: Gregory W Albers

Collaborators: National Institute of Neurological Disorders and Stroke (NINDS), Medical University of South Carolina, University of Cincinnati, NINDS Stroke Trials Network (StrokeNet)

Intervention / Treatment: PROCEDURE: Endovascular Thrombectomy, DEVICE: Covidien MindFrame Capture Revascularization Device, DEVICE: Trevo Retriever, DEVICE: Solitaire™ FR Revascularization Device, DEVICE: Penumbra thrombectomy system

Lead Sponsor: Boehringer Ingelheim

Intervention / Treatment: DRUG: dabigatran etexilate, DRUG: optional ASA as comedication, DRUG: placebo to ASA, DRUG: placebo to optional ASA as comedication, DRUG: placebo to dabigatran etexilate, DRUG: ASA 100 mg