Lead Sponsor: Boston Scientific Corporation

Intervention / Treatment: DEVICE: Sentinel® Cerebral Protection System

Lead Sponsor: Genentech, Inc.

Intervention / Treatment: OTHER: Placebo, BIOLOGICAL: Tenecteplase

Lead Sponsor: University of Virginia

Collaborators: National Institute of Neurological Disorders and Stroke (NINDS), Medical University of South Carolina, Neurological Emergencies Treatment Trials Network (NETT)

Intervention / Treatment: DRUG: Standard Care control - sliding scale insulin to keep glucose less than 180 mg/dL, DRUG: IV insulin to maintain target glucose concentration of 80-130 mg/dL