Lead Sponsor: National Cancer Institute (NCI)

Intervention / Treatment: OTHER: Laboratory Biomarker Analysis, DRUG: Dexamethasone, RADIATION: Radiation Therapy, DRUG: Cyclophosphamide, DRUG: Cytarabine, DRUG: Prednisone, DRUG: Etoposide, DRUG: Vincristine Sulfate, DRUG: Methotrexate, DRUG: Dasatinib, DRUG: Clofarabine, DRUG: Mercaptopurine, DRUG: Thioguanine, DRUG: Doxorubicin Hydrochloride, DRUG: Pegaspargase, DRUG: Leucovorin Calcium, DRUG: Daunorubicin Hydrochloride, DRUG: Hydrocortisone Sodium Succinate

Lead Sponsor: National Cancer Institute (NCI)

Intervention / Treatment: OTHER: Questionnaire Administration, OTHER: Laboratory Biomarker Analysis, OTHER: Pharmacological Study, OTHER: Quality-of-Life Assessment, DRUG: Cytarabine, DRUG: Etoposide, DRUG: Bortezomib, DRUG: Sorafenib Tosylate, DRUG: Asparaginase, DRUG: Daunorubicin Hydrochloride, DRUG: Mitoxantrone Hydrochloride

Lead Sponsor: Children's Oncology Group

Collaborators: National Cancer Institute (NCI)

Intervention / Treatment: OTHER: Questionnaire Administration, OTHER: Laboratory Biomarker Analysis, DRUG: Dexamethasone, OTHER: Quality-of-Life Assessment, DRUG: Cyclophosphamide, DRUG: Cytarabine, DRUG: Vincristine Sulfate, DRUG: Methotrexate, DRUG: Mercaptopurine, DRUG: Thioguanine, DRUG: Doxorubicin Hydrochloride, DRUG: Pegaspargase, DRUG: Leucovorin Calcium