Lead Sponsor: University of North Carolina, Chapel Hill

Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Intervention / Treatment: BEHAVIORAL: Mediterranean diet, no caloric restriction, BEHAVIORAL: Hypocaloric, low carbohydrate diet, BEHAVIORAL: Hypocaloric, moderate low fat diet

Lead Sponsor: Rensselaer Polytechnic Institute

Collaborators: University of California, San Diego, Stanford University, University of Colorado, Denver, University of California, Santa Barbara, Harvard University

Intervention / Treatment: DEVICE: Artificial pancreas system (Algorithm + CGM + pump)

Lead Sponsor: Alessandro Doria

Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Emory University, University of Minnesota, University of Michigan, University of Colorado, Denver, University of Washington, Washington University School of Medicine, University of Toronto, University of Alberta, University of Calgary, University of Texas Southwestern Medical Center, Northwestern University Feinberg School of Medicine, Juvenile Diabetes Research Foundation, Albert Einstein College of Medicine, Joslin Diabetes Center, Steno Diabetes Center Copenhagen, BCDiabetes.Ca

Intervention / Treatment: DRUG: Placebo, DRUG: Allopurinol