Lead Sponsor: Yale University

Collaborators: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), University of Pennsylvania, University of California, San Francisco, Augusta University, Penn State University, University of Oklahoma, University of North Carolina

Intervention / Treatment: DRUG: Orlistat, OTHER: Caloric Restriction, OTHER: Moderate physical activity

Lead Sponsor: Yale University

Collaborators: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), University of Pennsylvania, University of California, San Francisco, Augusta University, Penn State University, University of Oklahoma, University of North Carolina

Lead Sponsor: University of California, San Francisco

Intervention / Treatment: DRUG: Letrozole, DRUG: Placebo oral tablet