Lead Sponsor: Johns Hopkins University

Collaborators: University of Pennsylvania, University of Rochester, University of California, San Francisco, Yale University, Stanford University, Columbia University, The Cleveland Clinic, Swedish Medical Center, Oregon Health and Science University, University of Virginia, Washington University School of Medicine, Icahn School of Medicine at Mount Sinai, Anne Arundel Health System Research Institute, University of Massachusetts, Worcester, Dignity Health

Intervention / Treatment: DRUG: Vitamin D3

Lead Sponsor: Genzyme, a Sanofi Company

Intervention / Treatment: DRUG: alemtuzumab GZ402673

Lead Sponsor: Genzyme, a Sanofi Company

Collaborators: Bayer

Intervention / Treatment: BIOLOGICAL: Interferon beta-1a, BIOLOGICAL: Alemtuzumab 12 mg, BIOLOGICAL: Alemtuzumab 24 mg