Lead Sponsor: National Cancer Institute (NCI)

Intervention / Treatment: OTHER: Pharmacological Study, DRUG: Dexamethasone, RADIATION: Radiation Therapy, DRUG: Cyclophosphamide, DRUG: Cytarabine, DRUG: Etoposide, DRUG: Vincristine Sulfate, DRUG: Methotrexate, DRUG: Vincristine, PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation, BIOLOGICAL: Blinatumomab, DRUG: Mercaptopurine, DRUG: Therapeutic Hydrocortisone, DRUG: Thioguanine, DRUG: Pegaspargase, DRUG: Leucovorin Calcium, DRUG: Asparaginase, DRUG: Mitoxantrone Hydrochloride, DRUG: Mitoxantrone

Lead Sponsor: Children's Oncology Group

Collaborators: National Cancer Institute (NCI)

Intervention / Treatment: OTHER: Questionnaire Administration, OTHER: Laboratory Biomarker Analysis, OTHER: Quality-of-Life Assessment, DEVICE: Medical Device Usage and Evaluation, OTHER: Educational Intervention, OTHER: Internet-Based Intervention

Lead Sponsor: Children's Oncology Group

Collaborators: National Cancer Institute (NCI)

Intervention / Treatment: PROCEDURE: Biospecimen Collection, DRUG: Cyclophosphamide, DRUG: Cytarabine, DRUG: Methotrexate, DRUG: Vincristine, DRUG: Calaspargase Pegol, PROCEDURE: Diagnostic Imaging, PROCEDURE: Bone Marrow Aspiration and Biopsy, BIOLOGICAL: Inotuzumab Ozogamicin, PROCEDURE: Lumbar Puncture, DRUG: Pegaspargase, DRUG: Leucovorin Calcium, DRUG: Asparaginase Erwinia chrysanthemi