Lead Sponsor: Mayo Clinic

Collaborators: Terumo BCT

Intervention / Treatment: PROCEDURE: Plasma exchange (PLEX)

Lead Sponsor: University of California, Los Angeles

Collaborators: National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS), Mayo Clinic, University of Pennsylvania, University of Minnesota, University of Utah, University of Chicago, National Multiple Sclerosis Society, University of Colorado, Denver, Washington University School of Medicine, Johns Hopkins University, University of New Mexico, Dartmouth-Hitchcock Medical Center, Ohio State University, University of Texas Southwestern Medical Center, University of Medicine and Dentistry of New Jersey, University of Kansas Medical Center

Intervention / Treatment: DRUG: Placebo, DRUG: Copaxone, DRUG: Estriol